Synvista Therapeutics Compounds in Research & Development

BXT-51072 and the Prevention of Myocardial Ischemia-Reperfusion Injury
Author: R. Asaf, et al
Source: Drug Design & Discovery, 2007, 4, 160-162

Haptoglobin Genotype Determines Myocardial Infarct Size in Diabetic Mice
Author: Shany Blum, Roy Asaf, Julia Guetta, Rachel Miller-Lotan, Rabea Asleh, Ran Kremer, Nina S. Levy, Franklin G. Berger, Doron Aronson, Xiaoming Fu, Renliang Zhang, Stanley L. Hazen and Andrew P. Levy
Source: Journal of the American College of Cardiology, Vol. 49, No. 1, 2007

Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension
Author: Zieman, SJ, et al.
Source: Journal of Hypertension 2007, 25:577-583

Prevention and Reversal of Diabetic Nephropathy in db/db Mice Treated with Alagebrium (ALT-711)
Author: Peppa /Brem /Cai /Zhang /Basgen /Li / Vlassara /Uribarri
Source: American Journal of Nephrology 2006;26:430–436

The Effect of Alagebrium Chloride (ALT-711), a Novel Glucose Cross-Link Breaker, in the Treatment of Elderly Patients With Diastolic Heart Failure
Author: Little MD, et al
Source: Journal of Cardiac Failure Vol. 11 No. 3 2005

Superior Renoprotective Effects of Combination Therapy With ACE and AGE Inhibition in the Diabetic Spontaneously Hypertensive Rat
Author: Davis BJ, et al
Source: Diabetologia, January 2004

The Breakdown of Pre-existing Advanced Glycation End-Products is Associated with Reduced Renal Fibrosis in Experimental Diabetes
Author: Forbes J, et al
Source: Federation of American Societies in Experimental Biology (FASEB) Journal, published online, July 2003

Glycation End-product Cross-link Breaker Reduces Collagen and Improves Cardiac Function in Aging Diabetic Heart
Author: Liu J, et al
Source: American Journal Physiology Heart Circulatory Physiology, December 2003

A Cross-Link Breaker Has Sustained Effects on Arterial and Ventricular Properties in Older Rhesus Monkeys
Author: Vaitkevicius PV, et al
Source: Proceedings of the National Academy of Sciences, January 2001

Improved Arterial Compliance by a Novel Advanced Glycation End-Product Crosslink Breaker
Author: Kass DA, et al
Source: Circulation, September 2001

ALT-711, A Collagen Cross-link Breaker, Decreases Myocardial Fibrosis and Improves Endothelial Dysfunction in Hypertensive Dahl Salt Rats
Author: Veronsi M, et al
Source: Presented at the American Heart AssociationÂ’s 55th Annual Fall Conference and Scientific Sessions of the Council for High Blood Pressure, September 2001